A U.K. patient with a severely weakened immune system had COVID-19 for almost a year and a half, scientists reported, underscoring the importance of protecting vulnerable people from the coronavirus.
There's no way to know for sure whether it was the longest-lasting COVID-19 infection because not everyone gets tested, especially on a regular basis like this case.
But at 505 days, "it certainly seems to be the longest reported infection," said Dr. Luke Blagdon Snell, an infectious disease expert at the Guy's & St. Thomas' NHS Foundation Trust.
Snell's team plans to present several "persistent" COVID-19 cases at an infectious diseases meeting in Portugal this weekend.
Their study investigated which mutations arise -- and whether variants evolve -- in people with super long infections. It involved nine patients who tested positive for the virus for at least eight weeks. All had weakened immune systems from organ transplants, HIV, cancer or treatment for other illnesses. None were identified for privacy reasons.
Repeated tests showed their infections lingered for an average of 73 days. Two had the virus for more than a year. Previously, researchers said, the longest-known case that was confirmed with a PCR test lasted 335 days.
Persistent COVID-19 is rare and different from long COVID.
"In long COVID, it's generally assumed the virus has been cleared from your body but the symptoms persist," Snell said. "With persistent infection, it represents ongoing, active replication of the virus."
Each time researchers tested patients, they analyzed the genetic code of the virus to make sure it was the same strain and that people didn't get COVID-19 more than once. Still, genetic sequencing showed that the virus changed over time, mutating as it adapted.
The mutations were similar to the ones that later showed up in widespread variants, Snell said, although none of the patients spawned new mutants that became variants of concern. There's also no evidence they spread the virus to others.
The person with the longest known infection tested positive in early 2020, was treated with the antiviral drug remdesiver and died sometime in 2021. Researchers declined to name the cause of death and said the person had several other illnesses.
Five patients survived. Two cleared the infection without treatment, two cleared it after treatment and one still has COVID-19. At the last follow-up earlier this year, that patient's infection had lasted 412 days.
Researchers hope more treatments will be developed to help people with persistent infections beat the virus.
"We do need to be mindful that there are some people who are more susceptible to these problems like persistent infection and severe disease," Snell said.
Although persistent infections are rare, experts said there are many people with compromised immune systems who remain at risk of severe COVID-19 and who are trying to stay safe after governments lifted restrictions and masks started coming off. And it's not always easy to know who they are, said Dr. Wesley Long, a pathologist at Houston Methodist in Texas, who was not part of the research.
"Masking in crowds is a considerate thing to do and a way we can protect others," he said.
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Israel warned U.S. Defence Secretary Lloyd Austin in a call Tuesday that a military operation was going to take place in Lebanon but gave no details, U.S. officials said Thursday. The same day of the call, in an attack widely blamed on Israel, thousands of pagers belonging to Hezbollah militants exploded.
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A judge in a rural Kentucky county was shot and killed in his courthouse chambers Thursday, and the local sheriff was charged with murder, police said.
A 22-year-old woman who became an abortion rights advocate after she was raped by her stepfather as a child tells her story in a new campaign ad for Democratic presidential nominee Kamala Harris.
South Korea’s government, western countries and adoption agencies worked in tandem to supply some 200,000 Korean children to parents overseas, despite years of evidence they were being procured through questionable or downright unscrupulous means, an investigation led by The Associated Press found.
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Lebanese authorities on Thursday banned walkie-talkies and pagers from being taken on flights from Beirut airport, the National News Agency reported, after thousands of such devices exploded during a deadly attack on Hezbollah this week.
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Nike Inc. said Thursday it has named Elliott Hill as its president and CEO, replacing John Donahoe, who will retire next month.
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The mayor of Fort Saskatchewan apologized on Thursday for comments she made earlier this week about killing feral cats.
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Thomas Hamp says he believed secret police were out to kidnap, torture, and kill him when he fatally stabbed his girlfriend Emily Sanche in February of 2022.
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Newfoundland and Labrador's chief medical officer is monitoring the rise of whooping cough infections across the province as cases of the highly contagious disease continue to grow across Canada.
A 16-year-old biennial event aimed at fostering business in the country's eastern Arctic and northern regions has been cancelled indefinitely as a dispute unfolds between Inuit in Canada and a Labrador group claiming to share their heritage.
Jim Lester’s farm hopped on the cow-cuddling trend in early August, and his time slots have been pretty well sold out ever since.
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