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Health

    • 'Next wave' of cancer treatments trains immune system to target illness: doctor

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    Multiple provinces are investing in a form of T-cell therapy that could offer hope for cancer patients who are running out of treatment options, according to an Ontario physician.

    Chimeric antigen receptor (CAR) T-cell therapy is a new treatment that targets certain types of blood cancers, specifically forms of leukemia and lymphoma. T-cells are a type of white blood cell that play a role in immune response to illness.

    Dr. Natasha Kekre, a hematologist at The Ottawa Hospital, told CTV’s Your Morning Friday that this treatment is the “next wave†of cancer therapies where doctors can take a patient’s immune system, and target it to a specific cancer protein.

    “When we take those T-cells out from a patient’s own immune system, we take it to the lab, we re-engineer it, and then we re-infuse it into a patient to really target their own cancer,†she said.

    Kekre led the first clinical trial of Canadian-made CAR T-cells in 2019in conjunction with the Ottawa Hospital and BC Cancer and will help lead a national trial starting this year run by the National Research Council, a federal government agency that leads research and development.

    The trial was announced Feb. 3 and will begin later in 2023 in Toronto, Vancouver and Ottawa.

    In other parts of the country, Manitoba announced in January that it will invest $6.6 million into its own CAR T-cell program, with the aim of launching in the spring. Manitoba physicians described the therapy as “high-quality evidence-based treatment†that can be life-saving, in a press release about

    “It really allows for a much more targeted therapy toward their cancer, which is very different than chemotherapy and radiation which is very toxic and a general therapy. This is much more specific to their cancer,†she said.

    This type of therapy can target other forms of cancer outside of leukemia and lymphoma, she said. “Hopefully it will target lots of cancers that are difficult to treat.â€

    From Kekre’s trial that began in 2019, 30 patients have been treated so far and 13 have had “complete responses,†meaning that no more cancer can be detected in their blood. Two others have had partial responses, five have had their cancer progress and nine have died from cancer.

    It’s important that the infrastructure for clinical trials continues to be built, she said.

    “I hate to see this amazing technology in other countries going into clinical trials, taking five to 10 years to reach market access, and then coming to Canada— that’s just so unfair for our patients,†she said.

    She said the National Research Council trial allows physicians to bring new science to patients more quickly.

    For more information on the trials and treatment, watch the full interview with Dr. Kekre above.

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    Since she was a young girl growing up in Vancouver, Ginny Lam says her mom Yat Hei Law made it very clear she favoured her son William, because he was her male heir.

    The province's public security minister said he was "shocked" Thursday amid reports that a body believed to be that of a 14-year-old boy was found this week near a Hells Angels hideout near Quebec City.

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    The Montreal couple from Mexico and their three children facing deportation have received a temporary residence permit.

    Canada

    • Emergency crews in northern Ontario found the bodies of four people inside a home where a fire broke out Thursday night.

    • Since she was a young girl growing up in Vancouver, Ginny Lam says her mom Yat Hei Law made it very clear she favoured her son William, because he was her male heir.

    • A field trip aimed at educating Toronto students about the plight of a northern Ontario First Nation ended with them taking part in a protest where pro-Palestinian slogans were shouted.

    • The Montreal couple from Mexico and their three children facing deportation have received a temporary residence permit.

    • The second-degree murder trial of Thomas Hamp is being adjourned until December so an expert witness central to the trial can testify.

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    Entertainment

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    • They say a dog is a man’s best friend. In the case of Darren Cropper, from Bonfield, Ont., his three-year-old Siberian husky and golden retriever mix named Bear literally saved his life.

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      BREAKING NEWS

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    Autos

    • An Ontario man says it is 'unfair' to pay a $1,500 insurance surcharge because his four-year-old SUV is at a higher risk of being stolen.

    • Video of a brazen daylight auto theft which shows a suspect running over a victim in a stolen luxury SUV has been released by police west of Toronto.

    Local Spotlight

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    A growing group of brides and wedding photographers from across the province say they have been taken for tens of thousands of dollars by a Barrie, Ont. wedding photographer.

    Paleontologists from the Royal B.C. Museum have uncovered "a trove of extraordinary fossils" high in the mountains of northern B.C., the museum announced Thursday.

    The search for a missing ancient 28-year-old chocolate donkey ended with a tragic discovery Wednesday.

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    It's been a whirlwind of joyful events for a northern Ontario couple who just welcomed a baby into their family and won the $70 million Lotto Max jackpot last month.

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    Edmontonians can count themselves lucky to ever see one tiger salamander, let alone the thousands one local woman says recently descended on her childhood home.

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    • The Ford government is considering restricting Ontario municipalities from installing new bike lanes that would require the removal of lanes of traffic, a source confirms to CTV News Toronto.

    • For the last seven-and-half months, Toronto resident Heather McArthur has been living out what she describes as her 'worst nightmare.' On Feb. 7, her then three-year-old son Jacob along with his father Loc Phu 'Jay' Le departed for what was supposed to be a week-long visit to Vietnam to celebrate the Lunar New Year with family, McArthur says.

    • A field trip aimed at educating Toronto students about the plight of a northern Ontario First Nation ended with them taking part in a protest where pro-Palestinian slogans were shouted.

    • Defence counsel for accused murderer John-Christopher Arrizza argues he was in an “altered state of mind†due to days of drug and alcohol use, sleep deprivation and not eating, when he fatally stabbed a man at a Banff nightclub in 2022.

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    • BREAKING NEWS

      BREAKING NEWS

      Agreement to build a new NHL arena at LeBreton Flats has been reached between the Ottawa Senators and the National Capital Commission (NCC), sources tell CTV News Ottawa.

    • Police say a man, 34, who was taken to hospital in critical condition after being shot Thursday night has died.

    • The Ford government is considering restricting Ontario municipalities from installing new bike lanes that would require the removal of lanes of traffic, a source confirms to CTV News Toronto.

    • The Montreal couple from Mexico and their three children facing deportation have received a temporary residence permit.

    • Environment Minister Steven Guilbeault has invited his Quebec counterpart to the negotiating table to reach an agreement on caribou before Christmas. He noted that the province could benefit from hundreds of millions of dollars in funding to protect biodiversity.

    • The province's public security minister said he was "shocked" Thursday amid reports that a body believed to be that of a 14-year-old boy was found this week near a Hells Angels hideout near Quebec City.

    • DEVELOPING

      DEVELOPING

      Edmonton police are warning about traffic disruptions on Friday near the headquarters of the Alberta Teachers' Association, where a protest against the inclusion of sexual orientation and gender identity in school curricula will be taking place.

    • A mother and daughter say they woke up to flames encroaching on their third-floor apartment near Commonwealth Stadium early Friday morning.

    • WEATHER

      WEATHER

      The big weather story today won't really be rain, it'll be the cooler and breezier conditions.

    • A Nova Scotia woman has applied for a medically assisted death, saying after years of battling to receive out-of-country surgery for an illness that causes "indescribable" pain, she struggles to maintain the will to live.

    • Gas prices increased in all three Maritime provinces for the first time in more than a month.

    • A section of Herring Cove Road in the Spryfield area of Halifax is closed to traffic in both directions following a single-vehicle collision Friday morning.

    • The Winnipeg Police Service (WPS) has made an arrest following a fire that claimed the lives of two people.

    • Shamattawa RCMP are searching for a missing six-year-old boy who hasn’t been seen since Wednesday morning.

    • A Winnipeg pet rescue is putting out a warning to dog owners across the city about a possible parvovirus in the province.

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    • Regina police, fire and EMS were called to a three vehicle collision Friday morning outside the CTV News building.

    • The second-degree murder trial of Thomas Hamp is being adjourned until December so an expert witness central to the trial can testify.

    • Amber and Adam Brueckner have a pool-shaped hole in their backyard – and their wallets.

    • The missing family that was last seen in Kitchener, Ont. on Sept. 1 has been found safe, according to police.

    • A 43-year-old Guelph woman is wanted after police say she broke into a house and made herself at home.

    • The second-degree murder trial of Thomas Hamp is being adjourned until December so an expert witness central to the trial can testify.

    • A gym teacher at a private Christian school in Saskatoon has been charged. Terra MacEwan, 44, is charged with assault with a weapon. A Saskatoon mother who spoke with CTV News says her autistic son was MacEwan's victim.

    • Driving into the tunnels of Nutrien's Rocanville mine, the largest potash mine in the world by production volume, feels like driving down a lonely highway in the middle of the night.

    • Emergency crews in northern Ontario found the bodies of four people inside a home where a fire broke out Thursday night.

    • Two people emerged unhurt after a float plane had a hard landing late Friday morning on Lake Temiskaming.

    • Today, the 71 year old is marking 50 years a paramedic. He said he never aspired to move into management or a desk job, he enjoys being on the road, helping patients too much.

    • Around 2:20 a.m. on Sept. 15, police were called to the area of Richmond Street and Mill Street for a report of an assault — a man fled the aera on foot before officers arrived.

    • A research team in London is looking into whether or not ChatGPT can be used as a diagnostic tool for medical learners and clinicians.

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    • On Thursday, just after 9:30 a.m., a man was found and taken to police headquarters, where he was released with conditions and a future court date.

    • Tourism Windsor Essex Pelee Island (TWEPI) has launched a new visual journey, called “Eyes on Artâ€.

    • In a rare move, the Greater Victoria School District Board of Education has been slapped with a ministerial order from the province requiring it to update a student safety plan – drawing concern around political posturing leading up to an election.

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    • The Red Bridge, a historic landmark in Kamloops, B.C., was completely destroyed by fire early Thursday morning.

    • Animal protection officers in British Columbia have rescued three pit bulls – including one that gave birth to 10 puppies – from a rat-infested home in Kelowna.

    • A Vulcan, Alta., man has been charged with a Lethbridge woman's murder after her body was found in the Oyen area.

    • A Lethbridge couple got a good reminder as to why you should keep your vehicle doors locked at all times.

    • Lethbridge residents who live near the police range can expect to hear plenty of shots fired Wednesday and Thursday.

    • A new community health profile in the Algoma District shows the area is significantly below provincial averages in a number of health metrics.

    • North Bay Police Service says one person has died following an industrial accident at the Ontario Northland Transportation Commission Rail Yard on Tuesday.

    • Three northern Ontario residents are charged with drug trafficking after the vehicle they were in got stuck along a bush road off Highway 17 on Monday.

    N.L.

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