TORONTO -- Growing evidence about the powers of psilocybin, a naturally occurring psychedelic compound produced by several species of mushrooms, being used to treat anxiety and depression has inspired advocates to file a federal court challenge next month to allow its use to treat terminally ill patients.
Psychotherapist and professor at the University of Victoria Bruce Tobin has been on the forefront of those advocating to end the prohibition of the drug 鈥 highlighting its potential for cancer patients who often suffer from what is described by doctors as 鈥渆nd of life distress.鈥
End of life distress is a 鈥渘asty combination of anxiety, depression hopelessness and demoralization that often accompanies the diagnosis of a terminal illness such as cancer,鈥 Tobin said in an interview with CTV News鈥 medical correspondent Avis Favaro. 鈥淢y desire is to get the treatment to patients who are in need of it right now.鈥
Psilocybin found in what is colloquially known as 鈥渕agic mushrooms鈥 is illegal in Canada, but Tobin said he has witnessed patients undergoing psychotherapy feel calmer and less stressed by using the compound.
鈥淲e can see the results in many cases very quickly, as quickly as the next day,鈥 he said.
Tobin says he has been waiting three years for Health Canada to respond to multiple applications for psilocybin鈥檚 compassionate use in terminally ill patients.
鈥淢y attitude now is treatment delayed is treatment denied,鈥 Tobin said, explaining that he will continue to push for psilocybin to be exempted from the Controlled Drugs and Substances Act.
Three thousand patients per year in Canada are suffering from 鈥渆nd of life distress鈥 and fit the criteria for so-called psilocybin-assisted psychotherapy, Tobin said.
His campaign is supported by a group he formed, entitled 鈥,鈥 which lists the scientific, legal and moral reasons the group believes the compound should be made legal for 鈥渆nd of life distress鈥 cases.
Research into the medicinal uses of psilocybin has been growing exponentially.
A showed that cancer patients who were given the compound reported reductions in anxiety, depression, hopelessness, demoralization and death-related anxiety more than four years after receiving their doses in combination with psychotherapy.
A suggested that when given to patients with treatment-resistant depression, psilocybin affected 鈥渇unctional connectivity鈥 changes in the brain which was evident in scans. The study suggested that 鈥減silocybin therapy improves how the brain works and revives emotional responsiveness.鈥
The field of psychedelic research is 鈥渧ery exciting鈥 according to professor Roland Griffiths, director of the Center for Psychedelic and Consciousness at Johns Hopkins University in Baltimore.
Griffiths鈥 centre was the first to obtain regulatory approval in the U.S. to restart research into psychedelics using healthy volunteers. Previous research into psychedelics met an abrupt end during the war on drugs in the 1970s.
鈥淲hen we initiated this research there was a fair bit of skepticism on the part of many, my colleagues and certainly regulators, about whether or not this work is safe,鈥 Griffiths said in an interview with CTV News.
Now his research group is publishing an array of studies on the benefits of using one dose of psilocybin in a treatment that runs approximately six hours and has few side effects and displays benefits to patients鈥 perceptions.
鈥淧silocybin produces conditions under which people report having a sense of increased efficacy, a change of world view, a sense of change of self, and that they鈥檙e able to reengage in the world in very positive ways,鈥 Griffiths said.
Griffiths said that as patients reflect back on those experiences with psilocybin, they 鈥渙ften have this sense of a profound coming to an understanding of a deeper level of who they are.鈥
With many psychiatric disorders proving difficult to treat, Griffiths said the team at Johns Hopkins is expanding its testing of psilocybin and other psychedelics, such as LSD, for conditions including obsessive compulsive disorder, post-traumatic stress disorder, opioid use disorder, alcoholism and anorexia nervosa.
Other research is examining the benefits of microdosing, which uses small doses of psilocybin to treat anxiety and depression. A found 44 per cent of them perceived their mental health was 鈥渕uch better鈥 as a result.
Some Canadians are not waiting for the studies.
Michael Ljubsa of Edmonton, Alta., struggled with depression when he left high school and began university, and said he was unable to find relief with the standard therapies or medications available to him.
鈥淚 just became like a zombie basically,鈥 he said in an interview with CTV News. 鈥淚t became just difficult to function.鈥
Ljubsa experimented with psilocybin in Jamaica, where it is legal, to try and help 鈥 not something doctors recommend 鈥 and described a change in self-perception he found 鈥渓iberating鈥 and boosted his mental wellbeing. He is now an advocate of further psilocybin research.
鈥淎ny sort of work that is being done to bring this medicine to people as fast as possible is the work that needs to be done,鈥 Ljubsa said.
At least two centres in Canada are pursuing studies of psilocybin. The University of Toronto Mississauga has and will host the world鈥檚 first clinical trials on microdosing psilocybin. Other related research is planned at the University of British Columbia鈥檚 School of Population and Public Health.
鈥淚 think we are entering a new era in the treatment of mental health conditions,鈥 Griffiths said.
鈥淧silocybin and these compounds have mechanisms unlike anything we have seen within our normal treatment options within psychiatry,鈥 he continued. 鈥淭he potential鈥o have efficacy across a range of conditions is absolutely remarkable. We just don鈥檛 understand the mechanisms of them yet.鈥
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With files from Cillian O'Brien
