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    • What we know about Japan's contaminated Moderna COVID-19 vaccine supplies

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    Japan's COVID-19 vaccination push has been dealt a blow by widening reports of contamination in supplies of Moderna Inc's COVID-19 vaccine.

    Here are some key points in the issue so far.

     

    WHEN WAS IT FIRST REPORTED AND HOW HAS IT WIDENED?

    On Aug. 16, the first contamination was reported to Takeda Pharmaceutical Co, Moderna's local distributor.

    That led to the discovery of 39 vials containing foreign material in them, all from the same lot of 57,000 vials or about 570,000 doses.

    On Aug. 26, Japan said it had halted the use of 1.63 million Moderna doses shipped to 863 vaccination centers nationwide as a precaution.

    It suspended the use of lot 3004667 that included those vials and two similarly sized lots - 3004734 and 3004956.

    On Sunday, a vaccination center in Okinawa prefecture reported that contaminants were found in Moderna vials from a fourth lot 3005293.

    Black substances were spotted in syringes and a vial, while pink substances were found in a different syringe, the health ministry said.

    Also on Sunday, Gunma prefecture, near Tokyo, found a tiny, black substance in a Moderna vial, which differed from the four already suspended. The Gunma lot, whose number has not yet been disclosed, was also suspended.

    Following the two Sunday incidents, the use of about 1 million additional doses have been suspended.

     

    WHAT ARE THE CONTAMINANTS?

    The contaminants are believed to be metallic particles, public broadcaster NHK reported, citing health ministry sources.

    The ministry has not officially said what the particles are, pending an investigation by Takeda, Moderna, and its Spanish contract manufacturing partner Rovi. Those companies have also yet to comment on what the foreign material is.

     

    IS THERE A SAFETY ISSUE?

    Japan and Moderna have said no safety issues had been identified.

    Two men, aged 38 and 30, died this month within days of receiving their second Moderna doses, the health ministry said on Saturday. Each had one shot from one of the suspended lots, 3004734. The causes of death are being investigated.

    Both men had a fever the day after their second dose and died two days after getting the fever. There has been no evidence that their shots contained contaminants, a health ministry official told reporters.

    As of Aug. 8, 991 people had died in Japan after receiving COVID-19 shots from Pfizer/BioNTech, and 11 after receiving Moderna's. No causality between the injections and the deaths has been established, according to the health ministry.

    About 500,000 people have gotten shots from the first three suspended batches, Taro Kono, the minister in charge of the vaccine push, told reporters on Friday.

     

    ARE OTHER COUNTRIES ALSO AFFECTED?

    Rovi, which bottles Moderna vaccines for markets other than the United States, said last week the batch in question was meant for distribution only in Japan.

    South Korea, which also receives the Moderna vaccines produced from sites in the United States and Spain, said it was not affected by the issue.

    The European Union drugs regulator said last week it was investigating the incident but did not find reasons to seek a temporary suspension of production after an initial assessment.

    (Reporting by Rocky Swift in Tokyo; Editing by Miyoung Kim and Himani Sarkar)

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